• Shreya Pandey
• Dr. Janki Prasad Rai
• Dr. Manju Prajapati
• Dr.Akhlesh Kumar Singhai

This study aims to formulate and evaluate a niosome loaded gel containing Waltheria Indica extract for its antimicrobial activity. Niosomes, as vesicular carriers, offer advantages such as enhanced drug delivery and stability. The gel formulation provides a suitable topical delivery system for effective application. The Waltheria Indica extract, known for its antimicrobial properties, is incorporated into the niosome gel to harness its therapeutic potential. Various formulations of niosome gels were prepared using different ratios of surfactants and cholesterol to optimize the formulation. The prepared niosome gels were characterized for particle size, pH, Spreadability and entrapment efficiency. The niosomes showed high entrapment efficiency, with a viscosity of 5981±0.51cps, a ph of 6.2, and spreadability of 11.01. The antimicrobial activity of the optimized formulation was evaluated against selected microbial strain. As the concentration of the niosomal gel increases from 0.5 mg/ml to 2 mg/ml, there is a noticeable increase in the zone of inhibition, indicating enhanced antimicrobial activity against E. Coli. The results demonstrated promising antimicrobial efficacy, indicating the potential of the developed niosome gel as a topical antimicrobial agent.

"Formulation and evaluation of Niosomal loaded herbal gel of Waltheria Indica for Anti -microbial activity ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.i211-i221, May-2024, Available :http://www.jetir.org/papers/JETIR2405828.pdf

"Formulation and evaluation of Niosomal loaded herbal gel of Waltheria Indica for Anti -microbial activity ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppi211-i221, May-2024, Available at : http://www.jetir.org/papers/JETIR2405828.pdf