• Vidya krushna Sahare
• Archana kadam
• Rutuja Avhad
• Vaishnavi Palde

The aim of this article is to present a review of mucoadhesive drug delivery system.the review covers the mucoadhesive concepts,polymers used,theories and mechanisms of mucoadhesion,and factors affecting the mucoadhesive dosage forms. To overcome the relatively short gastrointestinal (GI) time and improve localization for oral controlled or sustained release drug delivery systems, bioadhesive polymers that adhere to the mucin/epithelial surface are effective and lead to significant improvement in oral drug delivery. Improvements are also expected for other mucus-covered sites of drug administration. Bioadhesive polymers find application in the eye, nose, and vaginal cavity as well as in the GI tract, including the buccal cavity and rectum. This article lays emphasis mainly on mucoadhesive polymers, their properties, and their applications in buccal, ocular, nasal, and vaginal drug delivery systems with its evaluation methods. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).

Keywords- Bioadhesive,Degradation, polymers ,Mucoadhesive , Evaluation, physicochemical, mucin

"Mucosal Drug Delivery system", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.n742-n755, April-2024, Available :http://www.jetir.org/papers/JETIR2404D92.pdf

"Mucosal Drug Delivery system", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppn742-n755, April-2024, Available at : http://www.jetir.org/papers/JETIR2404D92.pdf