• Nikita Gadade
• Dr . Tarke S.R
• Chavhan C.G.

The main objective of this article, is to improve the oral bioavailability of the drug substances in animals or humans. The self-emulsifying drug delivery system (SEDDS) is the one of the best proven method for poorly soluble drug substances by improving its solubility and bioavailability. The SEDDS is the mixture of oils, surfactant, cosurfactant, which are further emulsified with the help of aqueous media by following the various conditions like gently stirring and digestive motility that would be come across in the gastrointestinal tract. The conventional development of these formulations depend on actual observation to approach drug and excipient compatibility, as well as to select and optimize the formulation composition. The ability of SEDDS formulations to improve oral bioavailability has been allocated to a number of mechanisms, especially through increased apparent solubility of highly lipophilic drugs, as well as reduced metabolism or efflux. SEDDS is considered as a best platform for oral delivery of hydrophobic drug in order to overcome their poor and asymmetrical bioavailability challenges.

SEDDS, NDDS, AUC, Nanoparticles, Liposomes, Drug efficacy.

"REVIEW ON NOVEL DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.e758-e768, May-2024, Available :http://www.jetir.org/papers/JETIR2405490.pdf

"REVIEW ON NOVEL DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppe758-e768, May-2024, Available at : http://www.jetir.org/papers/JETIR2405490.pdf