• Dr. Pralhad Rege
• Dr. Vaibhav Salvi

In present study, a successful attempt has been made to develop a simple method for the simultaneous determination of cefixime and ofloxacin using Differential Pulse Polarography (DPP) technique. Quantification of cefixime and ofloxacin was done in Britton-Robinson Buffer of pH 5.0 using 1M KCl as a supporting electrolyte. Both cefixime and ofloxacin exhibit reduction cathodic peak in given pH with peak potential at -1.006 V for cefixime and -1.24 V for ofloxacin vs. S.C.E. 50% methanol-water solution was used as Solvent for the analysis. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of cefixime and ofloxacin in combined drug formulation. The proposed method has been validated. The limit of detection and limit of quantification for cefixime in the standard solution was 7.39 μg/ml and 45.45 μg/ml while for ofloxacin in the standard solution was 4.98 μg/ml and 24.30 μg/ml respectively. The same validated method was successfully used in quantification of drugs in urine as well.

Differential Pulse Polarography (DPP), cefixime, ofloxacin, Britton-Robinson Buffer, Quantification

"ELECTROANALYTICAL STUDY FOR SIMULTANEOUS QUANTIFICATION OF CEFIXIME AND OFLOXACIN FROM PHARMACEUTICAL DOSAGE FORMULATION AND ITS DETERMINATION IN URINE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.f361-f371, May-2024, Available :http://www.jetir.org/papers/JETIR2405540.pdf

"ELECTROANALYTICAL STUDY FOR SIMULTANEOUS QUANTIFICATION OF CEFIXIME AND OFLOXACIN FROM PHARMACEUTICAL DOSAGE FORMULATION AND ITS DETERMINATION IN URINE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppf361-f371, May-2024, Available at : http://www.jetir.org/papers/JETIR2405540.pdf