• Debjit Adhya
• Rimpa Laha
• Dr. Mithun Bhowmik
• Dr. Pratibha Bhowmik
• Shouvik Kumar Nandy

The project aimed to produce particle formulations based on chitosan (CH) for the transport of vancomycin (VM) to the colon. Different technological procedures were used to prepare chitosan nanoparticles (NPs) loaded with VM. With significant physicochemical and biological characteristics like biocompatibility, biodegradability, nontoxicity, non-immunogenicity, bio adhesion, and antibacterial, antifungal, and hemostatic action, chitosan is a linear polysaccharide. Because of its unique chemical structure, chitosan can be modified in certain ways. It also works well as a drug nanocarrier when chitosan particles are smaller than nanoscale. In this work, tripolyphosphate (TPP) was used as a cross-linker to facilitate the ionotropic gelation process that produced chitosan nanoparticles (CSNPs). The outcomes verified that vancomycin was effectively loaded onto chitosan nanoparticles. Moreover, it has been noted that 40% of the vancomycin is released in bursts during the first nine hours, and that the medication is then slowly released until 90% is released at the hundred-hour.

Drug release, Vancomycin, Chitosan nanoparticles, Cross-linker, Polysaccharide

"A comprehensive analysis of the utilization of chitosan-based nanoparticles loaded with Vancomycin for the purpose of targeted medication delivery in the treatment of Colitis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.g115-g128, May-2024, Available :http://www.jetir.org/papers/JETIR2405617.pdf

"A comprehensive analysis of the utilization of chitosan-based nanoparticles loaded with Vancomycin for the purpose of targeted medication delivery in the treatment of Colitis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppg115-g128, May-2024, Available at : http://www.jetir.org/papers/JETIR2405617.pdf