• J. Mandarika

Diabetes mellitus is a prevalent metabolic disorder characterized by elevated blood glucose levels, often accompanied by metabolic disturbances. In this study, we investigate the potential therapeutic effects of Emblica officinalis (Amla) extract on lactate levels in Alloxan-induced diabetic mice. Alloxan-induced diabetes in rodents serves as a model for type 1 diabetes and is associated with altered glucose metabolism and lactate production. Mice were divided into two groups: diabetic mice treated with Emblica officinalis extract and diabetic control mice. After a specified treatment period, blood lactate levels were assessed using enzymatic assays. Our results reveal a significant reduction in blood lactate concentrations in the Emblica officinalis-treated group compared to the diabetic control group. This finding suggests that Emblica officinalis extract may have a regulatory effect on lactate metabolism in diabetic mice. Additionally, no adverse effects of the extract were observed during the study period, indicating its safety. These preliminary findings warrant further investigation into the mechanisms underlying the observed lactate-lowering effect of Emblica officinalis and its potential as an adjunct therapy for managing diabetes-related metabolic abnormalities. This study contributes to our understanding of the therapeutic potential of natural compounds in diabetes management and opens avenues for future research in this field.

Diabetes mellitus is a prevalent metabolic disorder characterized by elevated blood glucose levels, often accompanied by metabolic disturbances. In this study, we investigate the potential therapeutic effects of Emblica officinalis (Amla) extract on lactate levels in Alloxan-induced diabetic mice. Alloxan-induced diabetes in rodents serves as a model for type 1 diabetes and is associated with altered glucose metabolism and lactate production. Mice were divided into two groups: diabetic mice treated with Emblica officinalis extract and diabetic control mice. After a specified treatment period, blood lactate levels were assessed using enzymatic assays. Our results reveal a significant reduction in blood lactate concentrations in the Emblica officinalis-treated group compared to the diabetic control group. This finding suggests that Emblica officinalis extract may have a regulatory effect on lactate metabolism in diabetic mice. Additionally, no adverse effects of the extract were observed during the study period, indicating its safety. These preliminary findings warrant further investigation into the mechanisms underlying the observed lactate-lowering effect of Emblica officinalis and its potential as an adjunct therapy for managing diabetes-related metabolic abnormalities. This study contributes to our understanding of the therapeutic potential of natural compounds in diabetes management and opens avenues for future research in this field.

"Emblica officinalis Extract and Lactate Levels in Alloxan-Induced Diabetic Mice: A Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.1, Issue 7, page no.212-218, December-2014, Available :http://www.jetir.org/papers/JETIR1701A25.pdf

"Emblica officinalis Extract and Lactate Levels in Alloxan-Induced Diabetic Mice: A Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.1, Issue 7, page no. pp212-218, December-2014, Available at : http://www.jetir.org/papers/JETIR1701A25.pdf