• Doctor Hetal

Diethanolamine is highly reactive compound with two functional groups alcohol and amine. It is used in pharmaceutical, cosmetic and agricultural industries. It is well known for its cumulative toxicity. Plant based antioxidants are well known since ancient times for its protective effect against toxicity generated by toxicants. Curcumin is a potent antioxidant active compound of turmeric plant root, known for its health benefits. Diethanolamine cytotoxicity was examined in human red blood corpuscles. Intravenous blood samples were collected from healthy volunteers to study hemolysis. RBC suspension was prepared in phosphate buffer saline and was incubated with various doses of DEA (25-1000 μg/ml) and varying concentrations of curcumin (25-100 μg/ml ) at 37 ºC for 1 hour. Amount of hemolysis were noted. Statistical analysis was performed using the analysis of variance (ANOVA) followed by Dunnett’s test and the level of significance was accepted with *p<0.05. The results revealed that DEA caused concentration-dependent increase in hemolysis. Whereas curcumin treatment significantly reduced the amount of hemolysis induced by DEA. Ameliorative potency of curcumin may be because of its antioxidant properties that aids into human health.

hemolysis, diethanolamine, amelioration, curcumin, cytotoxicity

"DIETHANOLAMINE-INDUCED CYTOTOXICITY ON ERYTHROCYTES AND ITS AMELIORATION BY CURCUMIN: AN IN VITRO ANALYSIS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1-5, May-2019, Available :http://www.jetir.org/papers/JETIR1905101.pdf

"DIETHANOLAMINE-INDUCED CYTOTOXICITY ON ERYTHROCYTES AND ITS AMELIORATION BY CURCUMIN: AN IN VITRO ANALYSIS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1-5, May-2019, Available at : http://www.jetir.org/papers/JETIR1905101.pdf