• DR LEKHAN K G
• Dr. MOHAMMED FAISAL
• Dr. NIVEDITHA SHETTY
• Dr. CHAKRAVARTULA ADHITYA

Abstract: The stress filled lifestyle and unwholesome food and regimen followed by human beings has led to alterations in the activities of psycho-neuro-endocrine systems causing newer health challenges like hyperthyroidism. Hyperthyroidism is the grievous condition characterized by hyper metabolism of the body that needs attention with respects to proper management as it hampers the quality of life. There is no exact explanation of the hyperthyroidism in Ayurvedic classics but it can be correlated to Bhasmaka roga. Acharya Sushrutha has mentioned the usage of Mahisha ksheera and gritha in bhasmaka roga. The scientific evidence behind this are not yet accomplished. Hence this experimental study has been designed to evaluate its preclinical efficacy in the disease. Objectives: To evaluate and compare the efficacy of Mahisha ksheera in Bhasmaka roga and Mahisha gritha in Bhasmaka roga w.s.r to Hyperthyroidism in Wister albino rats Methodology: Twenty-four albino rats of either sex were selected and assigned to 4 groups of 6 each. The 1st group served as normal rats. 2ND group are the positive control group where hyperthyroidism is induced by administration of thyroxin without trial drug. 3rd group is the test group where Rats induced with thyroxin are administered with Mahisha ksheera. 4th group is the test group where Rats induced with thyroxin are administered with Mahisha gritha. Drugs are administered for the duration of 30 days. Later the efficacy of the drugs is assessed by various Psycho-neuro-pharmacological and Endocrine activity profile by certain well known Neuropsychological tests and Blood investigations. At the end of the study hematological parameters and histopathological study of thyroid gland were assessed. Results and conclusion : Study concludes that both the test drugs Mahisha Ksheera and Mahisha gritha has a good effect on reversing the increased thyroid hormone secretion in hyperthyroidism as it helps to mitigate the sign and symptoms of the disease form remarkable to moderate level in experimental study. When compared to both the test drugs Mahisha ksheera has the remarkable effect than Mahisha gritha in the management of Bhasmaka roga w.s.r. to Hyperthyroidism.

Key words –Atyagni; Hyperthyroidism; Thyroxin induced Hyperthyroidism; Buffalo milk; Buffalo ghee; thyrotoxicosis

"COMPARATIVE EXPERIMENTAL STUDY TO EVALUATE THE EFFICACY OF MAAHISHA KSHEERA AND MAAHISHA GRITHA IN BHASMAKA ROGA W.S.R.TO HYPERTHYROIDISM”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 10, page no.d572-d578, October-2021, Available :http://www.jetir.org/papers/JETIR2110365.pdf

"COMPARATIVE EXPERIMENTAL STUDY TO EVALUATE THE EFFICACY OF MAAHISHA KSHEERA AND MAAHISHA GRITHA IN BHASMAKA ROGA W.S.R.TO HYPERTHYROIDISM”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 10, page no. ppd572-d578, October-2021, Available at : http://www.jetir.org/papers/JETIR2110365.pdf