• Ishani Chowdhury
• Dr. Surendra Vada
• Febisha A
• Sushree Swaraj
• Manjunatha PM

Zebrafish serves as a powerful tool to understand Acute Kidney Disease (AKD). Zebrafish models have been used to mimic clinical manifestations of renal failure, but they lack in specific structures for understanding the overall development. The development of the renal system, the genes related to the progression of AKI and its recovery in zebrafish have been mentioned. HNF-1 also known as hepatocyte nuclear factor and ATF3 or Activating Transcription Factor has also been considered a potential therapeutic target. Zebrafish have a pair of ambiguous genes namely, wt1a and wt1b for regeneration of nephrons. Various drugs such as nonsteroidal anti-inflammatory medicines, angiotensin converting enzyme inhibitors and aminoglycoside antibiotics have been discussed upon as models for AKD in zebrafish. Various biomarkers of kidney disease such as Neutrophil gelatinase-associated lipocalin (NGAL) have been briefly mentioned. A review based on developmental stages of AKD followed by genes responsible for regeneration of kidney in zebrafish has been developed with special focus on common zebrafish models and its biomarkers. Zebrafish is a potential experimental model which can be extensively used to study human inherited diseases due to its fecundity, rapid development, optical transparency, and accessibility to genetic manipulation tools.

zebrafish, acute kidney injury, regeneration, HNF1, AFT3, NGAL

"Unlocking the Potential of Zebrafish: A Comprehensive Guide to Acute Kidney Disease Research", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.f690-f699, September-2023, Available :http://www.jetir.org/papers/JETIR2309584.pdf

"Unlocking the Potential of Zebrafish: A Comprehensive Guide to Acute Kidney Disease Research", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppf690-f699, September-2023, Available at : http://www.jetir.org/papers/JETIR2309584.pdf