• K.Suvarna
• P.sivalalitha
• B.Nagamani
• P.Madhavi latha
• P.Umadevi

The aim of the present work is to study the solubility of class-2 drugs by FTIR analysis. Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA. Avanafil is sold under the brand names Stendra and Spedra. Avanafil is a class 2 drug. Class 2 drug are Low Solubility and High Permeability Solubility of Pure drug is studied with various Excipients. Alteration of solubility is observed by using FTIR analysis and solubility studies. Higher amino acids are insoluble in water. Avanafil contains more number of amine groups which in turn increases the molar mass of the compound therefore it is low soluble in water. The obtained results indicate that the solubility of class-2 drug i.e AVANAFIL was enhanced when it is mixed with the Excipient Co-Povidine. The Co-Povidine reacts with Avanafil alters the higher amines in Avanafil which increases the polarity of the drug. Co-Povidine also converts the alkenes present in Avanafil which enhances the solubility.

Avanafil, Solubility, Co-Povidine, Class -2 Drugs

"An overview of solubility of Class-2 drugs by FTIR analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b603-b608, November-2023, Available :http://www.jetir.org/papers/JETIR2311170.pdf

"An overview of solubility of Class-2 drugs by FTIR analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb603-b608, November-2023, Available at : http://www.jetir.org/papers/JETIR2311170.pdf