• DR.J.CHRISTINAL
• DR.ANITA MARGRET
• SUNIL KUMAR

Methylmercury (MeHg) is highly toxic, and its principal target tissue in human is the nervous system, which has made MeHg intoxication a public health concern for many decades. Cynodon dactylon (Poacae) (CD) is a well-known traditional plant used as a folk remedy in treatment of many symptoms and diseases. The present study was designed to evaluate the effect of CD ethanolic seed extract (EECD) on MeHg-induced neurotoxicity in cerebellum of rats. Phytochemical screening was done to identify the presence of alkaloids and Flavanoids. The phyto chemical screening which had a high level of phenols and amino acids. This is further confirmed by the FT-IR profile which shows the peak at the specific functional groups. Male Wistar rats were administered with MeHg orally at a dose of 5 mg/kg b.w. for 21 days. Experimental rats were given MeHg and also administered with EECD (750 mg/kg, orally) 1 hr prior to the administration of MeHg for 21 days. After MeHg exposure, we observed that activities of catalase, superoxide dismutase, glutathione (GSH) peroxidase, and the level of GSH were reduced. Behavioral changes such as, decreased motor activity, and spatial short-term memory were noted down during MeHg exposure. EECD pre-treatment offered protection from these behavioral changes. These observations highlighted that EECD has a protective effect against MeHg-induced neurotoxicity.

Methylmercury, Cynodon dactylon, Cerebellum, Behavioral, FT-IR

"EFFECT OF Cynodon dactylon, ON METHYL MERCURY-an ENVIRONMENTAL POLLUTANT INDUCED NEUROTOXICITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b712-b718, November-2023, Available :http://www.jetir.org/papers/JETIR2311186.pdf

"EFFECT OF Cynodon dactylon, ON METHYL MERCURY-an ENVIRONMENTAL POLLUTANT INDUCED NEUROTOXICITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb712-b718, November-2023, Available at : http://www.jetir.org/papers/JETIR2311186.pdf