• S.UMA MAHESWARI
• SUSAN ALBY
• R.VINITHA
• S.NAGARAJAN

Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. The matrix type transdermal film of Sertraline was prepared by solvent evaporation method using two different polymers Eudragit E 100 & hydroxy propyl methyl cellulose (HPMC) in different ratios. Dibutyl phthalate was used as a plasticizer. The films were evaluated for physical properties such as thickness, percentage moisture absorption, percentage moisture loss, drug content, folding endurance and flatness. The in-vitro release studies were performed using USP dissolution apparatus. The optimized film was further evaluated for skin permeation, stability and skin irritation studies. The data obtained shows that the transdermal film F5 (Eudragit E 100 & HPMC at ratio of 2:1) had produced a highest drug release of 98 ±1.02% up to 24 hrs. When the release study was conducted for F5 on an animal skin there was a drastic decrease (61.56 ± 0.14%) in the percentage of drug release. The kinetics of drug release followed higuchi model with diffusion controlled mechanism. Skin irritation studies showed no sign of edema and erythema. There was no interaction found between the drug and polymer as proved by FTIR studies. The prepared film of Sertraline is found to provide a controlled release and permeation which is suitable for transdermal delivery.

Transdermal Delivery, Sertraline, Hydroxy Propyl Methyl Cellulose, Eudragit E 100, In-vitro Evaluation, Skin Permeation

"Formulation and Evaluation of Transdermal Films of Anti-depressant drug Sertraline using Eudragit E100, HPMC ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.c567-c576, November-2023, Available :http://www.jetir.org/papers/JETIR2311278.pdf

"Formulation and Evaluation of Transdermal Films of Anti-depressant drug Sertraline using Eudragit E100, HPMC ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppc567-c576, November-2023, Available at : http://www.jetir.org/papers/JETIR2311278.pdf