• Kumail Hussain
• Mrs. Roshan Zehra
• Dr.Amarjeet Singh
• Mrs. Deepika Chauhan

ABSTRACT The formulations were subjected to various physiochemical studies and in vitro permeation studies. The influence of β – cyclodextrin on the in vitro percutaneous absorption of Glibenclamide (GBM) and its combined effect with propylene glycol (PG) and oleic acid (OA) was studied using Franz-type diffusion cell using a cellophane membrane. The receiver solution was phosphate buffer (pH 7.4). The permeability study was carried out for 12 hours. To increase the aqueous solubility of GBM, it was incorporated as its inclusion complex with β – cyclodextrin. The inclusion complex was thoroughly characterized using techniques, including differential scanning calorimetry and scanning electron microscopy.

Keywords : Glibenclamide, β – cyclodextrin, propylene glycol, oleic acid,Skin permeability,Transdermal gel.

"A Review Article on Formulation and evaluation of Glibenclamide transdermal gel ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.f531-f536, November-2023, Available :http://www.jetir.org/papers/JETIR2311561.pdf

"A Review Article on Formulation and evaluation of Glibenclamide transdermal gel ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppf531-f536, November-2023, Available at : http://www.jetir.org/papers/JETIR2311561.pdf