• DR. SHOBHA B NADAGOUDA
• DR. CHANDRIKA S RAO
• DR. L. S. METRI

PMS is a condition of recurrent physical and psychological symptoms occurring in a cyclic fashion during the 1st to 2nd week period preceding a woman’s menstrual period. As many of 85% of menstruating women report one or more mild premenstrual symptoms. Only 10% of women report significant impairment in lifestyle. PMDD, a variant of PMS that entails more severe psychologic symptoms and impairment of functioning, occurs in 2% to 9% of women reproductive age. Serotonin, sex steroids (Allopregnanolone) and GABA receptors, elevated testosterone levels, and a genetic basis are all implicated in the pathogenesis of PMS.60% of PMS patients respond to SSRIs. Methods: 30 Patients were divided in 2 groups, 15 patients in each. One group is named as Trial group in which prepared drug is given to patients for treatment; another group was named as control group in which placebo tablets are given to patients for treatment. Three follow-ups are taken in both groups for three consecutive cycles each. The study is single blind study. Results: 100% patients were cured after third follow-up in trial group while 40% were cured and 60% were improved in control group.

PMS; PMDD; SSRIs; GABAA.

"“COMPARATIVE PLACEBO CONTROLLED CLINICAL STUDY ON THE EVALUATION OF SHATAVARI GUDA IN ARTHAVA DOSHA WITH SPECIAL REFERENCE TO PRE MENSTRUAL SYNDROME”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 12, page no.e603-e609, December-2023, Available :http://www.jetir.org/papers/JETIR2312473.pdf

"“COMPARATIVE PLACEBO CONTROLLED CLINICAL STUDY ON THE EVALUATION OF SHATAVARI GUDA IN ARTHAVA DOSHA WITH SPECIAL REFERENCE TO PRE MENSTRUAL SYNDROME”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 12, page no. ppe603-e609, December-2023, Available at : http://www.jetir.org/papers/JETIR2312473.pdf