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December-2023
eISSN: 2349-5162
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Journal of Emerging Technologies and Innovative Research ( An International Scholarly Open Access Journal, Peer-reviewed, Refereed Journal )
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UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975
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JETIR2312591
Registration ID:
530632
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Title
Computational Approaches to Understanding Mosquito Insecticide Resistance: Genomic Insights into Esterase Dynamics
Authors
Abstract
In this article, the molecular details of mosquito pesticide resistance are examined, with a focus on the function of detoxification genes, namely the carboxylesterase gene family. The study investigates resistance mechanisms, highlighting gene duplication, amplification, and genetic alterations. It discusses the evolution of monitoring techniques from traditional bioassays to molecular methods like microarrays and PCR. The three-dimensional organization of the enzyme superfamily is examined, emphasizing the alpha/beta hydrolase fold protein.The study presents a comparative nucleotide sequence analysis of mosquito esterase genes, revealing divergence among species. Nucleotide composition analysis indicates biases, and amino acid composition analysis identifies crucial residues. Exon-intron analysis uncovers variations in splice sites, suggesting functional constraints. Multiple sequence alignment and phylogenetic analysis provide insights into evolutionary relationships. In conclusion, the article discusses the significance of esterase genes in disease control amid increasing insecticide resistance. Future research priorities include structural investigations and functional characterizations, promising advancements in insect biochemistry.
Key Words
Anopheles,Aedes,Culex,Insecticide resistance mechanisms,Detoxification genes, Phylogenetic analysis, Functional conservation,Computational genomics,Vector-borne diseases
Cite This Article
"Computational Approaches to Understanding Mosquito Insecticide Resistance: Genomic Insights into Esterase Dynamics", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 12, page no.f750-f759, December-2023, Available :http://www.jetir.org/papers/JETIR2312591.pdf
ISSN
2349-5162 | Impact Factor 7.95 Calculate by Google Scholar
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Cite This Article
"Computational Approaches to Understanding Mosquito Insecticide Resistance: Genomic Insights into Esterase Dynamics", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 12, page no. ppf750-f759, December-2023, Available at : http://www.jetir.org/papers/JETIR2312591.pdf
Publication Details
Published Paper ID: JETIR2312591
Registration ID: 530632
Published In: Volume 10 | Issue 12 | Year December-2023
Page No: f750-f759
Country: Bhiwani, Haryana, India .
Area: Biological Science
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIR2312591
Published Paper PDF: https://www.jetir.org/papers/JETIR2312591
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