• Mr. Mulaje S.S
• Mr. Choudhary A.U
• Mr. Usnale R.D
• Mr. Kondapure A. A.
• Dr. Chaus W.N.

Immediate release drug delivery system is conventional type of drug delivery system designed to disintegrate and release their medicaments with no special rate controlling features such as special coatings and other techniques. This work encloses the immediate release pharmaceutical formulation by film coating for oral administration for treatment of renal graft. Film coating involves deposition of thin uniform film of polymer formulation surrounding tablet by spraying method. Macrolide is an antibiotic with immunosuppressive category belong to BCS class-II. The bioavailability of Macrolide drug is low due to its poor water solubility, so it is difficult to formulate it into a suitable dosage form. To overcome this, the Macrolide drug layer is to film coated on to the sugar barrier coated tablets using the film former, film coated drug layer is followed by sugar over coating of the tablets. The identity of Macrolide was confirmed by various physical characteristics, spectrophotometric analysis such as UV spectrophotometric and FTIR, and thermal behavior like melting point and crystalline character of Macrolide by X-ray diffraction. Use of excipients in the formulation and their concentrations used are on trial and error basis and formulation batches are formulated. Formulated immediate release tablet of Macrolide was evaluated for friability, hardness, thickness, weight variation, disintegration time, % drug release & accelerated stability studies.

Macrolide, Immunosuppressive, innovator, placebo tablet, BCS Class II drug, allograft, micronization

"FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET OF MACROLIDE BY MICRONIZATION METHOD.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 1, page no.h127-h160, January-2024, Available :http://www.jetir.org/papers/JETIR2401714.pdf

"FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET OF MACROLIDE BY MICRONIZATION METHOD.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 1, page no. pph127-h160, January-2024, Available at : http://www.jetir.org/papers/JETIR2401714.pdf