• Mukesh Kumar
• Rekha Kumari
• Arun Kumar

In India, an estimated 70 million population are exposed to arsenic due to drinking of contaminated groundwater. In state of Bihar about 10 million people are exposed to arsenic poisoning. Out of 38 districts of the state, 18 districts are severely affected. The exposed population exhibit various symptoms such as skin manifestations - hyperkeratosis, melanosis, loss of appetite, neuro-behavioral disorders etc. Therefore, the present study aims to develop novel drug discovery against arsenic induced toxicity in Charles Foster rat models. After the ethical approval from the Institutional Animal Ethics Committee, the animals were grouped into 03, the first group was the control group, the second group was arsenic treated and the third group was Vinca rosea leaf extract treated upon arsenic pre-treated group. In the arsenic treated group, the rats received sodium arsenite orally at the dose of 8 mg/kg body weight daily for 90 days followed by administration of Vinca rosea leaf extract at the dose of 300 mg/kg body weight daily by gavage method for 60 days. Their biochemical levels like liver and kidney function tests were assayed and were found with elevated levels. Furthermore, their free radical assessment such as lipid peroxidation levels were assayed which was also found to be many folds higher. Furthermore, the arsenic concentration in the tissue of liver and kidney was significantly very high. But, after the administration of ethanolic leaf extract of Vinca rosea, there was significant restoration in the biochemical and lipid peroxidation levels. Moreover, there was also reduction in the arsenic content in the liver and kidney tissues of rats. The entire study reveals that, Vinca rosea possesses therapeutic effect against arsenic induced toxicity.

Charles Foster rats, arsenic induced model, biochemical assays, liver and kidney toxicity, Vinca rosea leaf extract, therapeutic effects.

"Therapeutic Effect Of Vinca rosea Against Arsenic Induced Toxicity In Charles Foster Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.e85-e100, February-2024, Available :http://www.jetir.org/papers/JETIR2402412.pdf

"Therapeutic Effect Of Vinca rosea Against Arsenic Induced Toxicity In Charles Foster Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppe85-e100, February-2024, Available at : http://www.jetir.org/papers/JETIR2402412.pdf