• Mainuddin
• Javeria Khan
• Prithvi Sharma
• Amulya Jindal
• Abhishek Kumar

In the realm of drug delivery, the paradigm shift towards precision and efficacy has catalyzed the evolution of lipid-based nanoformulations. This review endeavors to provide an exhaustive exploration of lipid-based nanoformulations, elucidating their pivotal role in achieving effective and targeted drug delivery. The core essence of lipid-based nanoformulations lies in their ability to encapsulate therapeutic agents within lipidic matrices, offering a versatile platform for enhanced drug solubility, bioavailability, and targeted delivery. The paper synthesizes information from a plethora of studies to elucidate the unique properties of lipid-based nanostructures that enable precise targeting of therapeutics to specific cells, tissues, or organs. The review begins by exploring the diverse range of lipid materials employed in nanoformulations, highlighting their biocompatibility, versatility, and ability to encapsulate a wide variety of drugs. Emphasis is placed on lipid nanoparticles, liposomes, ethosomes, and lipid-based micelles, each offering distinct advantages in terms of drug loading, stability, and release kinetics. Special attention is given to the design principles governing lipid-based nanoformulations, such as size, surface charge, and functionalization, and their impact on target-specific drug delivery. Furthermore, the review delves into the mechanisms underlying the enhanced permeability and retention (EPR) effect, which plays a pivotal role in the passive targeting of lipid-based nanoformulations to tumor tissues. Strategies to augment active targeting, including ligand conjugation and surface modification, are extensively discussed to enhance the specificity of drug delivery systems. In addition to cancer therapy, the paper explores the application of lipid-based nanoformulations in various therapeutic areas, including cardiovascular diseases, infectious diseases, metabolic disorder, gene therapy, vaccination and neurological disorders. The safety profile of lipid-based nanocarriers and their potential for personalized medicine are also examined. As lipid-based nanoformulations continue to evolve, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical scientists seeking a comprehensive understanding of the challenges, and future directions in the realm of lipid-based nanoformulations for effective targeting in drug delivery.

Lipid Nanoparticles, Liposomes, SLN, NLC, Cancer, Drug Delivery System, Lipid based drug carrier, Lipid based formulation

"Lipid-Based Nanoformulation in Drug Delivery for Precision Targeting and Enhanced Efficacy: Formulation and its Application", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.e492-e506, February-2024, Available :http://www.jetir.org/papers/JETIR2402473.pdf

"Lipid-Based Nanoformulation in Drug Delivery for Precision Targeting and Enhanced Efficacy: Formulation and its Application", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppe492-e506, February-2024, Available at : http://www.jetir.org/papers/JETIR2402473.pdf