• Tsegie Alemayehu
• Amanuel Shewakena

Abstract Background NTD is related to failure of neural tube closure between 3rd and 4th weeks of embryo development. NTD is divided into two categories: cranial and spinal defects. Anencephaly, encephalocele, and spina bifida are examples of NTD. Few studies have indicated a combined role for environmental and genetic factors in the development of NTD. So, the aim was to assess the factors associated with the development of NTD Method An unmatched case control study design was utilized on 245 mothers, 61 cases and 184 controls at AGH MCH center of Yekatit 12 specialized comprehensive teaching hospital located at the capital city of Addis Ababa Ethiopia. All conformed cases of NTD were included with 3 controls chosen by simple random sampling method. Data collected using electronic questionnaire and analysis was done by SPSS 27.0 and presented with significant P value of 0.05 and with 95% CI. Results Totally Six variables were found to be related to NTD development. primi gravidity (AOR:0.055, 95%CI: 0.007,0.416), gravidity 2-4(AOR:0.035,95 CI:0.006,0.238), Not having Previous pregnancy affected with NTD (AOR:0.079,95 % CI: 0.009,0.663) , Monthly family income in birr <5000 birr (AOR: 4.224, 95%CI : 1.344, 13.273), Not taking Preconception folic acid use (AOR : 9.600,95%CI 2.151-42.834), Known chronic illness mother (AOR: 8.561,95 % CI :1.510 48.518) , Not having Preconceptional care contact (AOR : 9.209, 95% CI :1.027-82.554) were found to be significantly associated with NTDs development . Conclusion Preconception care and taking preconceptional folic acid supplementation will reduce the odds of having NTD so they are recommended to prevent NTD, and on the other had having Increased number of pregnancies, low monthly income, having chronic medical illness and having previous NTD affected pregnancy was found to increase the odds developing NTD so we recommend to have increased follow up and if possible, to avoid preventable factors.

neural tube defect

"Determinants of neural tube defect (NTD) among mothers at Yekatit 12 Abebech Gobena MCH teaching hospital in Addis Ababa, Ethiopia, a case control study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.f17-f35, February-2024, Available :http://www.jetir.org/papers/JETIR2402503.pdf

"Determinants of neural tube defect (NTD) among mothers at Yekatit 12 Abebech Gobena MCH teaching hospital in Addis Ababa, Ethiopia, a case control study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppf17-f35, February-2024, Available at : http://www.jetir.org/papers/JETIR2402503.pdf