• Manoj Patowary
• Himani Kalita

Development of suitable matrix is vital in scaffold-guided tissue engineering application that could aid in cellular growth for tissue regeneration. Herein, nanocomposite film of polyvinyl alcohol (PVA)/montmorillonite (MMT)/zirconium phosphate (ZP) has been synthesized as potential matrix for scaffold-guided tissue engineering application via solvent casting method, where PVA was used as the polymer matrix, while MMT as well as ZP nanoparticles were used as the reinforcing bioactive fillers. The prepared nanocomposite film was characterized by various spectroscopic as well as microscopic techniques. The nanocomposite exhibits significant mechanical properties as observed in the nanoindentation tests (hardness = 0.1234 GPa and elastic modulus = 3.94 GPa at a load of 500 μN), while in-vitro cellular studies on the nanocomposite film using mouse 3T3 fibroblast cells revealed its superior bioactivity, thereby substantiating its applicability as a potential matrix in scaffold-guided tissue engineering application. Additionally, the nanocomposite displayed a controlled biodegradation rate in phosphate buffered saline (PBS) medium containing lysozymes with a residual mass > 62% on the 30th day. The developed nanocomposite also exhibits a controlled swelling behavior.

Nanocomposite; scaffold; tissue engineering; bioactivity; mechanical property

"Polyvinyl alcohol/Montmorillonite/Zirconium Phosphate Nanocomposite Film as potent matrix in Scaffold-guided Tissue Engineering Application", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.i61-i73, March-2024, Available :http://www.jetir.org/papers/JETIR2403809.pdf

"Polyvinyl alcohol/Montmorillonite/Zirconium Phosphate Nanocomposite Film as potent matrix in Scaffold-guided Tissue Engineering Application", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppi61-i73, March-2024, Available at : http://www.jetir.org/papers/JETIR2403809.pdf