• Rudraksh khadak
• Ashotosh badola

Formulators have always favored the oral route, which has dominated over alternative administration routes. Low and inconsistent bioavailability, primarily due to inadequate water solubility, is the main issue with oral medication formulations. Because of their limited bioavailability, over 40% of novel chemical entities have poor water solubility and pose a serious threat to the current drug delivery method. Drugs can become more soluble in water through a bunch of processes, including complex formation, solid dispersion, and salt production, but the Self Emulsifying Drug Delivery System (SEDDS) is receiving more attention as a means of enhancing the pharmaceuticals that are lipophilic and soluble. Ideally, SEDDS are isotropic blends of medication, oil, surfactant, and/or co surfactant. After being administered, these systems spread quickly in the gastrointestinal system. fluid, producing solubilized dug micro- and nano-emulsions.This results in in situ medication solubilization that allows it to be absorbed through lymphatic channels, avoiding the first-pass hepatic impact. This review provides a thorough overview of SEDDS, which shows promise as a solution to the issue of poorly soluble compounds.

self emulsifying drug delivery system, solubility, bioavalability, poorly-soluble, surfactants, cosurfactants

"Self emulsifying drug delivery system: a review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.k255-k262, March-2024, Available :http://www.jetir.org/papers/JETIR2403A35.pdf

"Self emulsifying drug delivery system: a review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppk255-k262, March-2024, Available at : http://www.jetir.org/papers/JETIR2403A35.pdf