• Shrutika Ghansolkar
• Dr. Itishree Vaidya

Proteins have a great relevance in bio-modification of metal nanoparticles and enhancing their bioactivity. Nanoparticles intended for drug delivery often fail to fully exploit their clinical potential due to limitations linked to their targeting ability and subsequent bio-distribution issues. In the current study, gold nanoparticles (AuNP) were synthesized by a sustainable method using gelatin as a bio-reducing agent. The AuNPs were produced by modulating temperature and reaction time as input parameters. The optimized AuNP has round shape, particle size of 58 nm, and characteristic surface plasmon resonance wavelength maxima at 530 nm. Functional evaluation of AuNP was performed using a model drug. For this, surface functionalization of AuNP with cysteine (cys) was performed followed by attachment of a model drug fluconazole (Flu) to give AuNP-Cys-Flu and evaluated for drug release.

Gelatin, Gold nanoparticles, Cysteine, AuNP-Cys-Flu, Drug delivery

"Design and development of AuNP-Cys-Flu system by a sustainable route", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.b660-b668, April-2024, Available :http://www.jetir.org/papers/JETIR2404174.pdf

"Design and development of AuNP-Cys-Flu system by a sustainable route", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppb660-b668, April-2024, Available at : http://www.jetir.org/papers/JETIR2404174.pdf