• Preethi Kattupalli
• P Srinivasa Babu
• M Dhanya
• T Annapurna
• S Pavan Kumar Reddy

The present study was carried out with an objective of preparation and in vitro evaluation of fenugreek mucilage floating tablets using Telmisartan as a model drug incorporated hydroxyl propyl methyl cellulose of two different grades were employed. Telmisartan (TEL) is a selective angiotensin II receptor blocker used in the management of cardiovascular disorders. It is a class II drug according to biopharmaceutics classification system with poor solubility and high permeability. Owing to its hydrophobicity, TEL demonstrates low dissolution behavior in gastro-intestinal (GIT) media ensuing deprived absorption, and later poor bioavailability. The Gastro Retentive Floating Tablets (GRFT) were formulated by means of hydroxy propyl methyl cellulose (HPMC) and naturally extracted binder from the seeds of Trigonella foenum (Fenugreek). Three batches were formulated by using two different grades of HPMC namely K15 and E50. These prepared formulas were examined for Drug-excipient incompatibility studies by FT-IR, angle of repose, Carr's Index (CI), Hardness, Weight variation, Floating Lag Time (FLT), Floating Duration (FD) and dissolution profile. It was concluded that by using HPMC K15 gives the better bioavailability when compared with the HPMC E50 and combination of both grades as a floating drug delivery system of Telmisartan.

Gastro Retentive Floating Tablets (GRFT), HPMC, Trigonella foenum (Fenugreek)

"FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF FENUGREEK MUCILAGE AS NATURAL BINDER USING TELMISARTAN AS A MODEL DRUG ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.b814-b828, April-2024, Available :http://www.jetir.org/papers/JETIR2404192.pdf

"FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF FENUGREEK MUCILAGE AS NATURAL BINDER USING TELMISARTAN AS A MODEL DRUG ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppb814-b828, April-2024, Available at : http://www.jetir.org/papers/JETIR2404192.pdf