• MAMTA SOLANKI

The healthy adult female albino rats (Rattus norvegicus) weighing 150-200 gm were exposed to fluoride (5.8ppm) contaminated drinking water for 60 days. The fluoride water exposure to female rats for 60 days resulted in an irregular estrus cycle significantly, reduced organ weights, fertility (60%), litter per rat, and estradiol concentration. The protein, glycogen, ascorbic acid, and cholesterol concentrations of the ovary and uterus were altered in the FW group. The enzyme activity of acid phosphatase SGOT and SGPT declined, whereas alkaline phosphatase increased in serum as well as in reproductive organs studied. The histological observations revalued vacuolization in the stroma and increased atretic follicle in the fluoride-treated rat ovary. Histology of the uterus showed a reduction in the uterine gland and thickness of the myometrium part of the uterus, structural changes were observed in the uterine layers by fluoride treatment in female rats. The data suggests that fluoride water induced adverse effects on an internal milieu of the reproductive organs of female albino rats and it also affects the pituitary-gonadal axis or directly on the target organ of the animal.

: Ovary, uterus, estrus cycle, antiestrogen, fluoride water.

"Fluoride-induced toxicity in the reproduction of female albino rats (Rattus norvegicus)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.f772-f780, April-2024, Available :http://www.jetir.org/papers/JETIR2404587.pdf

"Fluoride-induced toxicity in the reproduction of female albino rats (Rattus norvegicus)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppf772-f780, April-2024, Available at : http://www.jetir.org/papers/JETIR2404587.pdf