• Runita Sharad Karale
• Teena Dubey
• Prasad Kate
• Dr.Vilas Sawale
• Dr.Rajnikant kakade

Drug design is the part of pharmaceutical science with the vast history. Drug design in the Indian context has been a sophisticated pharmaceutical science since the late 19th century. Inspired by Emil Fisher’s analogy of drug-receptor interaction resembling a key & lock. Over the time, drug design has developed into a disciplined science with a robust theoretical foundation and practical applications. Currently, it stands as the latest & most advanced technique for discovering new drugs with the primary goal of developing effective, specific, innocuous, acceptable and reliable drugs. It integrates the scientific and technological advancements into a diverse range of methodologies and tools. The established knowledge of Quantitative Structural-Activity Relationship (QSAR) knowledge optimistically guides the selection of pharmaceutical targets to the pharmaceutical industries, as they are facing challenges in developing cost effective new molecule. Drug design is currently experiencing rapid advancements, is a forefront area of science, particularly influenced by the integration of artificial intelligence. This overview aims to highlight key milestones in drug design history, outline popular contemporary techniques and present the author’s perspective on future directions. However, it acknowledges that it does not claim to comprehensively cover the extensive range of drug design topic.

Drug design, QSAR, Computer Aided Drug Design (CADD), artificial intelligence, drug discovery and development.

"Evolution and Advancements in Drug Design: A Comprehensive Overview", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.h29-h37, April-2024, Available :http://www.jetir.org/papers/JETIR2404705.pdf

"Evolution and Advancements in Drug Design: A Comprehensive Overview", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. pph29-h37, April-2024, Available at : http://www.jetir.org/papers/JETIR2404705.pdf