• Dr Smita More
• Ms. Snehal Thorat
• Ms. Sanskruti Khedkar
• Ms Pratiksha Londhe
• Dr Shashikant Dhole

The current analysis aims to elucidate the latest developments in nasal medication delivery technology. The non-invasive nature of the nasal pathway makes the nasal route of administration useful for a wide range of therapeutic uses. The nasal route is significant and preferred over other invasive approaches like intravenous, intracerebral, and transcranial for the systemic delivery of drugs and the treatment of central nervous system (CNS) diseases like depression, Alzheimer's disease (AD), and Parkinson's disease (PD) via the nose-to-brain pathway because it avoids the blood-brain barrier (BBB) and the hepatic first-pass effect. There are obstacles in the way of effectively delivering medication to the brain through the nasal route. Dosage constraints imposed by the nasal route are among the limitations.Limitations include the effect of mucociliary clearance and dosage limitsto the nasal pathway. The effectiveness of the delivery mechanism used is a critical factor in the efficacy of nasal medication delivery. It has been confirmed that lipidic-based drug delivery systems have a positive effect on nasal delivery. Solid lipid nanoparticles, niosomes, and liposomes are a few of the well-researched lipidic carriers that have demonstrated promise for nasal medication administration. Enhanced stability, prolonged release patterns, and better drug solubility are just a few benefits of these lipid-based systems. Lipid bilayers, the building blocks of liposomes, are capable of encasing both hydrophilic and hydrophobic medications. Since niosomes are made of non-ionic surfactants, they are stable and biocompatible, which makes them appropriate drug delivery vehicles for the nose. Solid lipid nanoparticles, which are made of solid lipids, prevent pharmaceuticals against deterioration and offer controlled drug release. These lipidic-based drug delivery systems improve drug bioavailability and get around obstacles that prevent drugs from reaching the brain, hence addressing the problems related to nasal drug delivery. The possibility of lipidic-based nasal medication delivery systems to improve treatment results for CNS illnesses is highlighted by the current review in this field. As these technologies advance, they have the potential to completely transform the non-invasive nasal approach to treating neurological disorders. The purpose of this review is to examine nasal medication delivery methods, including their uses, formulations, benefits, absorption mechanisms, nasal anatomy, influencing factors, and current breakthroughs.

Nasal drug delivery, Noisome, Nanotechnology, Solid lipid nanoparticles.

"ENHANCING NASAL DRUG DELIVERY THROUGH NIOSOMAL INNOVATIONS: A SYSTEMATIC REVIEW ON FORMULATION, STRATEGIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.j606-j620, April-2024, Available :http://www.jetir.org/papers/JETIR2404976.pdf

"ENHANCING NASAL DRUG DELIVERY THROUGH NIOSOMAL INNOVATIONS: A SYSTEMATIC REVIEW ON FORMULATION, STRATEGIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppj606-j620, April-2024, Available at : http://www.jetir.org/papers/JETIR2404976.pdf