• SHREY DUBEY
• SHREY DUBEY
• MAHADEV KANERE
• AKHLESH KUMAR SINGHAI

Nanotechnology has emerged as a promising field in cancer therapy due to the unique properties exhibited by nanoparticles. These tiny particles, typically ranging from 1 to 100 nanometers in size, offer numerous advantages in the diagnosis, imaging, and treatment of cancer. This review summarizes the diverse applications of nanoparticles in cancer management. One of the key applications of nanoparticles in oncology is drug delivery. Nanoparticles can be engineered to encapsulate chemotherapeutic agents, shielding them from premature degradation and enhancing their accumulation at the tumor site through passive targeting via the enhanced permeability and retention effect. Additionally, surface functionalization of nanoparticles enables active targeting, facilitating specific interaction with cancer cells while minimizing off-target effects. In addition to drug delivery, nanoparticles play a crucial role in cancer imaging. Contrast agents based on nanoparticles offer superior imaging capabilities, enabling early detection, accurate diagnosis, and monitoring of therapeutic responses. Functionalization with targeting ligands further improves the specificity and sensitivity of imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), and fluorescence imaging. Furthermore, nanoparticles are being explored for their potential in cancer theranostics, combining therapy and diagnostics in a single platform. Theranostic nanoparticles can deliver therapeutic payloads while simultaneously providing real-time feedback on treatment efficacy, allowing for personalized and adaptive treatment strategies. Moreover, nanoparticles have shown promise in overcoming multidrug resistance, a significant challenge in cancer treatment. By modulating drug efflux mechanisms and bypassing resistance pathways, nanoparticle-based formulations have the potential to re-sensitize resistant cancer cells to chemotherapy..

Nanoparticles & its characters, Cancer, Cancer therapy, Current cancer treatment,Case studies and success stories.

"A REVIEW ON : APPLICATION OF NANOPARTICLES IN CANCER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.l1-l8, April-2024, Available :http://www.jetir.org/papers/JETIR2404B01.pdf

"A REVIEW ON : APPLICATION OF NANOPARTICLES IN CANCER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppl1-l8, April-2024, Available at : http://www.jetir.org/papers/JETIR2404B01.pdf