• GOKULNATH
• Kamali P
• Kavikumar

The rising prevalence of antibiotic resistance necessitates exploring novel bioactive compounds from natural sources. This study investigates the antimicrobial potential of Gracilaria edulis, is a marine red algae, through in vitro and in silico approaches. In vitro, bioactive compounds were extracted from Gracilaria edulis which using Chromatography technique and tested against clinical pathogens, including Gram-positive and Gram-negative bacteria, and fungi, using agar well diffusion method. In silico studies identified potential bioactive compounds and predicted their interactions with microbial enzymes and proteins via molecular docking simulations. Results demonstrated that Gracilaria edulis extracts exhibited substantial antimicrobial activity with notable inhibition zones and low Minimum Inhibitory Concentration (MIC) values. In silico analysis supported these findings, showing strong binding interactions between the compounds and microbial proteins. This study highlights Gracilaria edulis as a promising source of novel antimicrobial agents, integrating in vitro and in silico methods to pave the way for algae-based therapeutics against clinical pathogens.

Gracilaria edulis, antimicrobial activity, in vitro, in silico, clinical pathogens, molecular docking, gas chromatography, phytochemical analysis, Secondary Metabolism, bioactive compounds.

"Invitro and Insilco Studies of Gracilaria edulis against clinical pathogens", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.b82-b93, June-2024, Available :http://www.jetir.org/papers/JETIR2406111.pdf

"Invitro and Insilco Studies of Gracilaria edulis against clinical pathogens", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppb82-b93, June-2024, Available at : http://www.jetir.org/papers/JETIR2406111.pdf