• Sandesh Subhash Chavan
• Prathamesh Vinayak Waske
• Dhyanesh Sunil Chaudhari
• Ankita Arun Mali
• Kiran Dattatray Sable

An artificial triazole antifungal agent is called itraconazole. Itraconazole was prepared in a number of pharmacological forms with different delivery methods. To treat fungal infections in the lungs that have the potential to spread throughout the body, utilize itraconazole capsules. Since it is not yet listed as an official medication in any pharmacopoeia, there aren't many published methods for quality control and stability testing of itraconazole in pharmaceutical formulations. The current study aims to create a spectrophotometric method that is more accurate, straightforward, and cost-effective for analyzing itraconazole in both bulk and capsule dosage forms. Using chloroform as the solvent, UV spectroscopic determination was performed at an absorption maximum of 267 nm. Using the UV spectroscopic method, linearity was determined to be 1-10 μg/ml with a correlation coefficient of 0.999 over the concentration range of itraconazole. The analyses' conclusions were supported by recovery studies and statistical validation. The International Conference on Harmonization guidelines were followed in the study of parameters such as linearity, precision, accuracy, limit of detection, and limit of quantification in order to validate the method.

Pharmacopoeia, Itraconazole, Quality control, UV spectroscopic method.

"METHOD DEVELOPMENT & VALIDATION OF ITRACONAZOLE BY UV-SPECTROSCOPY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.b188-b196, June-2024, Available :http://www.jetir.org/papers/JETIR2406126.pdf

"METHOD DEVELOPMENT & VALIDATION OF ITRACONAZOLE BY UV-SPECTROSCOPY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppb188-b196, June-2024, Available at : http://www.jetir.org/papers/JETIR2406126.pdf