• Nabamita Sen
• Dr. Fowad Khurshid

Transdermal medication delivery is a highly efficacious approach to drug administration. Additionally, a lot of medications are unable to cross the stratum corneum, which serves as the primary transdermal drug barrier delivery. The synthesis of ultra-deformable vesicles (UDVs) is a revolutionary approach for medication delivery transdermally. The UDs includes ethosomes, transferosomes, and transethosomes (TEs). Many physical as well as chemical methods were developed to overcome stratum corneum barrier and deliver the drug to target site by this route of administration in medical fields. Transethosomes offer better medication penetration through the stratum corneum due to their higher ethanol, phospholipid, and edge activator concentrations. Drug penetration into the deeper layer of skin also rises as a result of TEs' flexibility. There are several methods for preparing TEs, such as the cold method, Hot method, Mechanical dispersion method, Ethanol injection method. In this review article various methods and approaches were discussed in detail about transethosomes. In future aspects various formulations can be made with this advanced technology in the field of drug delivery via. Transdermal as well as topical drug administration. In this article various mode of enhancement of drugs to cross the stratum corneum were discussed and also the advanced technologies through transdermal route like development of vesicular drug delivery system in the field of nanotechnology.

Transethosomes, Keratinocytes, SC, UDVs.

"A BRIEF REVIEW ON TRANSETHOSOMES - A NOVEL APPROACH TOWARDS TRANSDERMAL DRUG DELIVERY SYSTEM ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.b632-b647, June-2024, Available :http://www.jetir.org/papers/JETIR2406170.pdf

"A BRIEF REVIEW ON TRANSETHOSOMES - A NOVEL APPROACH TOWARDS TRANSDERMAL DRUG DELIVERY SYSTEM ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppb632-b647, June-2024, Available at : http://www.jetir.org/papers/JETIR2406170.pdf