• Gaurav mittal
• Pankaj Singh Niranjan

Diabetes, a prevalent metabolic disorder, poses significant challenges to health and quality of life globally. This study focuses on evaluating the Antidiabetic properties of aqueous extracts from three plants, Momordica charantia (bitter melon), Murraya koenigii (curry leaf), and Aloe vera, in comparison to Metformin, a widely used Antidiabetic drug. The research was conducted using alloxan-induced diabetic male albino rats, a common model for studying diabetes. The primary objective of this study was to assess how effectively the aqueous extracts of M. charantia, M. koenigii, and Aloe vera can lower blood glucose levels compared to Metformin. The secondary objective was to evaluate their impact on various biochemical parameters including serum creatinine, albumin, urea, serum glutamate oxaloacetate transaminase (SGOT), and serum pyruvate transaminase (SGPT), as well as their influence on body weight over a treatment period of 28 days. The extracts produced the following results, M. charantia at 300 mg/kg body weight significantly (p<0.05) decreased blood glucose levels to 109.8 ± 5.45 mg/dL; M. koenigii at 300 mg/kg significantly (p<0.05) decreased blood glucose levels to 109.2 ± 6.14 mg/dL; Aloe vera at 300 mg/kg significantly (p<0.05) decreased blood glucose levels to 112.2 ± 7.83 mg/dL; and Metformin at 150 mg/kg significantly (p<0.05) decreased blood glucose levels to 86.6 ± 4.27 mg/dL. For comparison, the blood glucose levels in the untreated control group were 88.8 ± 3.76 mg/dL. Each treatment group showed a statistically significant (p<0.05) reduction in blood glucose levels, indicating that the extracts effectively approached normal values. The study also evaluated changes in various biochemical parameters that are indicative of the body's metabolic state and organ functions. These improvements in biochemical parameters across all treatment groups suggest that the plant extracts not only helped in lowering blood glucose level but also had a beneficial effect on overall metabolic health.

Murraya Koenigii, Momordica charantia, Aloe vera, antidiabetic, activity, comparative study, Metformin

"Investigation of comparative antidiabetic effect of aqueous extract of Momordica charantia, Murraya koenigii and Aloe vera in alloxan induced male albino rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.c8-c19, June-2024, Available :http://www.jetir.org/papers/JETIR2406202.pdf

"Investigation of comparative antidiabetic effect of aqueous extract of Momordica charantia, Murraya koenigii and Aloe vera in alloxan induced male albino rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppc8-c19, June-2024, Available at : http://www.jetir.org/papers/JETIR2406202.pdf