• Akash Viswas
• Rahul mathur
• Dr. Jagdish Chandra Rathi

Eight batches of Herbal Antidandruff gel were formulated. All the formulated gels were subjected to Physiochemical evaluations such as Clearance, pH, Homogeneity, Spreadability, Extrudability, Viscosity, Drug content was evaluated. Based on the physicochemical evaluations formulation F5, F6, F7 and F8 were selected as the optimized gel formulation. For the above selected formulations, in-vitro release profiles were performed. The data obtained from in vitro release profile after 5 hours was fitted with various kinetic equations to determine the mechanism of active constituents release and release rate as indicated by higher correlation coefficients (r2). The active constituents release from gel formulation follows zero order and non-fickian diffusion. Base on the in-vitro release profile it was found that release of active constituents from prepared gels followed first order kinetics. The Antimicrobial screening result showed that the formulation F8 was highly inhibited the fungi and bacterial growth around the patch. So F8 was selected for further evaluations such as Skin irritation, Ex- vivo and stability studies. The stability studies were performed for the selected formulation (F8) by both the technique as per the ICH guidelines.

Polyhedral, Gel, Alopecia, Herbal, Dandruff

"Design and development of polyherbal gel for alopecia and dandruff management", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.d233-d243, June-2024, Available :http://www.jetir.org/papers/JETIR2406327.pdf

"Design and development of polyherbal gel for alopecia and dandruff management", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppd233-d243, June-2024, Available at : http://www.jetir.org/papers/JETIR2406327.pdf