• Nutan Bhikaji Sinare
• Ashwini More

It has been shown that chronic pain is an independent disease as well as an accompanying symptom of certain diseases. Interleukin-18 (IL-18), a proinflammatory cytokine with pleiotropic biological effects, is involved in immune modulation, the inflammatory response, tumor growth, and the chronic pain process. Compelling evidence suggests that IL-18 is upregulated in the development of chronic pain. Cancer-related chronic pain (CP) represents a critical clinical problem during the disease and significantly affects the quality of 0life (QoL) of patients and family environment. Neuropathic pain is defined as pain caused by an injury or disease of the somatosensory system. It can affect a single nerve, multiple nerves, or occur diffusely. The prevalence of neuropathic pain is 7 to 10% and has a significant impact on the general population. Neuropathic pain is a common complaint of patients with peripheral neuropathy (PN) and is considered one of the most disease neuropathic symptoms with adverse effects on patients quality of life. Antagonism or inhibition of IL-18 expression can alleviate the occurrence and development of chronic pain. And IL-18 is found in microglia, while IL-18R is found mainly in astrocytes in the spinal cord. This suggests that the interaction between microglia and astrocytes mediated by the IL-18/IL-18R axis is involved in the development of chronic pain. I However, IL-18 is mainly produced by activated macrophages; It can also be expressed by Kupffer cells, T cells, B cells, keratinocytes, astrocytes and osteoblasts.

Chronic pain, interleukin 18, cancer pain, neuropathic pain,peripheralneuropathic pain, Central neuropathic pain.

"Interleukin -18 in chronic pain: focus on pathogenic mechanisms and potential therapeutic targets", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.d804-d818, June-2024, Available :http://www.jetir.org/papers/JETIR2406400.pdf

"Interleukin -18 in chronic pain: focus on pathogenic mechanisms and potential therapeutic targets", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppd804-d818, June-2024, Available at : http://www.jetir.org/papers/JETIR2406400.pdf