• Sushil K. Pagariya
• Pravin S. Bodkhe

A series of 3,5-disubstituted-1-phenyl pyrazoles (6a-d) and 3,5-disubstituted isoxazoles (7a-d) incorporating 4-chloro-3-methylphenol viz. p-chloro-m-cresol moiety have been effectively synthesized and studied their impact on phytotic growth of some food grain and vegetable crop plants. Initially, 5-chloro-2-hydroxy-4-methylacetophenone (2) has been prepared by an acetylation of p-chloro-m-cresol followed by Fries rearrangement with anhydrous AlCl3. The acetophenone (2) on treatment with substituted aromatic carboxylic acids in dry pyridine with POCl3 affords substituted 2-benzoyloxy acetophenones (3a-d) which on Baker-Venkatraman transformation (BVT) in dry pyridine with pulverized KOH yielded corresponding 1-(5’-chloro-2’-hydroxy-4’-methylphenyl)-3-(substituted phenyl) propane-1,3-diones (4a-d) i.e. β-diketones. All the newly synthesized β-diketones underwent dehydrative cyclization in acidic media affords the respective 2-(substituted phenyl)-6-chloro-7-methyl-4H-chromen-4-ones (5a-d) as key intermediates which were refluxed with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in DMF solvent with small amount of piperidine yielded novel 3,5-disubstituted-1-phenyl pyrazoles (6a-d) and 3,5-disubstituted isoxazoles (7a-d) respectively. All the newly synthesized titled compounds were screened for their impact on phytotic growth of some food grain crop plants viz. Cicer arientinum, Glycine max, Vigna radiata, Vigna mungo and some vegetable crop plants viz. Solanum lycopersicum, Trigonella foenum-graecum and Capsicum annuum with reference to their shoot height and number of leaves at definite periodicity and found to have remarkable growth promoting, antifungal and antimicrobial activity on plants.

Pyrazoles, isoxazoles, p-chloro-m-cresol, phytotic growth, food grain and vegetable crop plants.

"Synthesis and Study of Impact of p-Chloro-m-cresol Incorporated Pyrazole and Isoxazole Derivatives on Phytotic Growth of Some Food Grain & Vegetable Crop Plants", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.f404-f412, June-2024, Available :http://www.jetir.org/papers/JETIR2406545.pdf

"Synthesis and Study of Impact of p-Chloro-m-cresol Incorporated Pyrazole and Isoxazole Derivatives on Phytotic Growth of Some Food Grain & Vegetable Crop Plants", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppf404-f412, June-2024, Available at : http://www.jetir.org/papers/JETIR2406545.pdf