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June-2024
eISSN: 2349-5162
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Journal of Emerging Technologies and Innovative Research ( An International Scholarly Open Access Journal, Peer-reviewed, Refereed Journal )
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UGC Approved Journal no 63975(19)
ISSN: 2349-5162 | ESTD Year : 2014 Call for Paper
Volume 11 | Issue 7 | July 2024
ISSN: 2349-5162 | ESTD Year : 2014 Call for Paper
Volume 11 | Issue 7 | July 2024
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UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975
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JETIR2406684
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543524
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Title
Reverse Phase-Hplc Method Development and Validation for the Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Metoprolol Succinate
Authors
Abstract
A simple, rapid, precise, accurate, economical and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the determination of Dapagliflozin Propanediol Monohydrate (DAP) and Metoprolol Succinate (MET) which was used in combined ratio of (1: 5) for treatment of patient suffering with Heart Failure.[1] The separation was achieved on a Shim-pack solar C18 (250 mm × 4.6 mm, particle size of 5 µ) using a mobile phase [Acetonitrile: Methanol: Water (pH 3.0 adjusted with 1% (OPA) Orthophosphoric Acid)] (72:3:25 %v/v/v). HPLC separation of DAP and MET was carried out detection of at 223 nm. The mobile phase was pumped at a flow rate of 1ml/min. The retention times of DAP and MET were found to be 4.245 min and 2.186 min respectively. Excellent linearity range was found between 2-6 µg/ml for DAP and 10-30 µg/ml for MET. The method was validated with respect to linearity, precision, accuracy, specificity and ruggedness. Method was successfully applied for the simultaneous determination of Dapagliflozin Propanediol Monohydrate (DAP) and Metoprolol Succinate (MET) in combined pharmaceutical dosage form synthetic mixture.
Key Words
Dapagliflozin Propanediol Monohydrate, Metoprolol Succinate, RP-HPLC, Method Validation
Cite This Article
"Reverse Phase-Hplc Method Development and Validation for the Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Metoprolol Succinate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.g738-g752, June-2024, Available :http://www.jetir.org/papers/JETIR2406684.pdf
ISSN
2349-5162 | Impact Factor 7.95 Calculate by Google Scholar
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Cite This Article
"Reverse Phase-Hplc Method Development and Validation for the Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Metoprolol Succinate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppg738-g752, June-2024, Available at : http://www.jetir.org/papers/JETIR2406684.pdf
Publication Details
Published Paper ID: JETIR2406684
Registration ID: 543524
Published In: Volume 11 | Issue 6 | Year June-2024
Page No: g738-g752
Country: Umargam, Gujarat, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIR2406684
Published Paper PDF: https://www.jetir.org/papers/JETIR2406684
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