• Manisha

Objectives: The aim of the present work was to formulate and evaluate fast dissolving tablets of non-steroidal anti-inflammatory drug (KT) by super disintegration and sublimation approach. Along with this a comparison between natural and synthetic super disintegrants was also done on the basis of disintegration time and drug release. Methodology: Tablets were prepared using direct compression method with camphor, ammonium bicarbonate and benzoic acid as subliming agent and sodium starch glycolate (SSG) and Plantago ovata mucilage as superdisintegrants. Results: All the pre-compression and post-compression parameters were determined and disintegration time (DT) and % drug release were also calculated to find the best formulation. Conclusion: Fast dissolving tablets of ketorolac tromethamine were prepared and formulation F1out of all containing camphor and SSG was found to be best formulation because of its best drug release rate in less time.

Super disintegration, disintegration time, drug release, Anti-inflammatory

"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF NON-STEROIDAL ANTI- INFLAMMATORY DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.h855-h864, June-2024, Available :http://www.jetir.org/papers/JETIR2406791.pdf

"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF NON-STEROIDAL ANTI- INFLAMMATORY DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. pph855-h864, June-2024, Available at : http://www.jetir.org/papers/JETIR2406791.pdf