• Prasanthi Teella

Abstract: Writing this essay on the floating drug delivery system (FDDS) had as its main goal organizing the latest research on the fundamental role that flotation plays in gaining gastric retention. The buoyancy mechanism served as the foundation for the various techniques utilized in the creation of FDDS, including the construction of both effervescent and noneffervescent floating tablets. Metformin HCl was created in an oral sustained-release floating tablet format.Metronidazole's continuous release floating pills may be a more sensible and effective way to provide superior therapeutic effects over time. In the current study, metronidazole floating tablets were effectively made employing a variety of concentrations through the use of sustained release polymers such as Xanthan gum, carbopol 934, and hydroxyl propyl methyl cellulose K100 in the dry granulation process.After analysis, it was determined that the post time, weight variation, friability, and other factors were within the official bounds. Comparing Carbopol 934 to the other medications, this one has a slower rate of dissolution. Based on the dissolution behavior analysis of all the formulations, F9 exhibits the best results, followed by F7 and F8. The best results are shown by this trio of formulations: that is the medication release just 57.2% at the ten –hour mark. As a result, the investigation found that Carbopol 934 exhibits.

Keywords: Floating drug delivery system, .Metronidazole, Xanthan gum, Carbopol 934,Hydroxylpropyl methyl cellulose K100.

"Formulation and Evaluation of Metronidazole Sustained Release Floating Tablets", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.i249-i255, June-2024, Available :http://www.jetir.org/papers/JETIR2406825.pdf

"Formulation and Evaluation of Metronidazole Sustained Release Floating Tablets", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppi249-i255, June-2024, Available at : http://www.jetir.org/papers/JETIR2406825.pdf