• Uma Kumari (first Author)
• Sharvari Santosh Kulkarni (First Author)
• Gurpreet kaur (Second Author)
• Ruchi Chaudhary (Second Author)

This study explores ATP-competitive type III c-MET inhibitors as potential therapeutics for glioma treatment using computational drug design methods. Structural data from extensive biological databases facilitated a comprehensive analysis of c-MET and related proteins, crucial for understanding their structural dynamics and functional implications. Advanced visualization techniques enabled detailed examination of protein structures, aiding in molecular modeling and interaction site identification.Docking analyses predicted binding affinities and interaction modes of potential inhibitors, including Cabozantinib, highlighting their specificity towards c-MET. Structural validation through energy score calculations and other validation methodologies ensured the accuracy of protein models. Interaction analyses provided insights into protein-ligand interactions and the identification of active sites.Moreover, protein-protein docking simulations elucidated complex interaction interfaces, contributing to understanding molecular mechanisms in protein-protein interactions. RMSD calculations quantified structural deviations between proteins, offering insights into their structural similarity and alignment quality. The color-coded RMSD spectrum facilitated visual assessment of alignment quality across different structural comparisons.This computational study advances our knowledge of ATP-competitive type III c-MET inhibitors in glioma therapy. The integrated approach of molecular modeling, docking simulations, and structural validation enhances the development of targeted therapeutics, providing a foundation for further experimental validation and potential clinical applications in glioma treatment.

Glioma Cancer,Structure Analysis, Therapeutic Targets, Procheck,Docking, Drug Discovery

"Structure Analysis And Glioma Targeted Therapeutics Cancer In ATP Competitive Type III C-MET Inhibitor", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.i271-i282, June-2024, Available :http://www.jetir.org/papers/JETIR2406827.pdf

"Structure Analysis And Glioma Targeted Therapeutics Cancer In ATP Competitive Type III C-MET Inhibitor", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppi271-i282, June-2024, Available at : http://www.jetir.org/papers/JETIR2406827.pdf