• Nwefuru Peace Chioma

Microemulgel due to its ability to solubilize poorly water soluble medicines and improve topical and systemic availability, microemulsions a lipid drug delivery system, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and/or cosurfactant, was selected for this study. The goal of this study was to create a lipid-based carrier of salicylic acid microemulsion base gel to improve its solubility and bioavailability while preserving controlled drug release at the targeted region. Initially, 9 formulations of microemulsion M1 to M9 was prepared by titration method using 3 different procedures which produced M9 prepared by procedure 3 containing 3% salicylic acid, 0.1% lecithin as lipid/oil, tween 80 and propylene glycol mixed in the ratio (1.6:1) as surfactant/co-surfactant, and 16% ethanol as cosolvent as the best stable microemulsion. According to the results, the new formulation was stable and created microemulsion compared to other M1 to M8. M9 was tested for particle size, zeta potential, polydispersity index, refractive index, viscosity, drug content, and release. M9 optimised formulation was combined with six different concentrations of carbopol 940 to create microemulsion gel. The appearance, viscosity spreadability, extrudability, drug content, and in vitro release studies of gels G1-G6 were all examined. The in-vitro release study of the formulation G5 was greater, showing that the produced formulation has higher solubility and permeability. Thus, it can be concluded that microemulsion gel formulation can be employed as one of the formulation techniques to improve the bioavailability of poorly soluble and insoluble compounds. It as will minimizes side effects of the medication while sustaining and releasing the drug in a controlled manner with time and minimal or no side effects.

Lipid drug delivery, microemulsion, microemulsion based gel, salicylic acid

"Development of Lipid Based Carrier Formulation For Poorly Soluble Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.d294-d363, July-2023, Available :http://www.jetir.org/papers/JETIRTHE2051.pdf

"Development of Lipid Based Carrier Formulation For Poorly Soluble Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppd294-d363, July-2023, Available at : http://www.jetir.org/papers/JETIRTHE2051.pdf